Found 8 matching trials
Microbiome Derived Metabolism and Pharmacokinetics
PHASE1The investigators will perform single-dose pharmacokinetic (PK) studies in ...
Location
Robert Wood Johnson University Hospital Somerset
Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR)
EARLY_PHASE1The purpose of this study is to determine whether Tolcapone crosses from th...
Location
Amyloidosis Center, Boston Medical Center
Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users
PHASE2The purpose of this study is to determine the effects of tolcapone on decis...
Location
University of California, Berkeley
Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors
PHASE4The purpose of this study is to determine whether oral intake of COMT inhib...
Location
Uppsala University Hospital
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
PHASE2The purpose of this study is to determine whether the catechol-O-methyltran...
Location
Medical University of South Carolina
COMT Inhibition Among Individuals With Comorbid AUD/ADHD
PHASE2The purpose of this study is to determine whether the catechol-O-methyltran...
Location
University of Colorado Anschutz Medical Campus
Effects of Tolcapone on Frontotemporal Dementia
PHASE2This study will test the effects of a medication called tolcapone on cognit...
Location
Columbia University Irving Medical Center
Trial of Tolcapone With Oxaliplatin for Neuroblastoma
PHASE1The purpose of this research study is to evaluate an investigational drug (...
Location
Arkansas Children's Hospital